Elaine F. Walker, Ph.D.

Selected Recent Publications

Cannon, T.D., Cadenhead, K. Cornblatt, B., Woods, S.W. Addington, J., Walker, E., Seidman, L. J., Perkins, D., Tsuang, M., McGlashan, T., Heinssen, R. (2008) Prediction of Psychosis in Youth at High Clinical Risk: A Multisite Longitudinal Study in North America. Archives of General Psychiatry. 65(1):28-37.

Compton MT. Bollini AM. McKenzie Mack L. Kryda AD. Rutland J.  Weiss PS. Bercu Z. Esterberg ML. Walker EF. (2007) Neurological soft signs and minor physical anomalies in patients with schizophrenia and related disorders, their first-degree biological relatives, and non-psychiatric controls. Schizophrenia Research. 94(1-3):64-73.

Mittal, VA. Tessner KD. Walker EF. (2007) Elevated social Internet use and schizotypal personality disorder in adolescents. Schizophrenia Research. 94(1-3):50-57.

Mittal, VA. Neumann C. Saczawa M. Walker EF. (2008)Longitudinal progression of movement abnormalities in relation to psychotic symptoms in adolescents at high risk of schizophrenia. Archives of General Psychiatry. 65(2):165-71.

 Mittal, VA. Saczawa, M & Walker, E. (2008) Prenatal exposure to viral infection and conversion among adolescents at high-risk for psychotic disorders. Schizophrenia Research, 99: 375-376.

Walker, E., Mittal, V., & Tessner, K (2008) Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annual Review of Clinical Psychology. Vol. 4: 189-216.

Walker, Elaine; Mittal, Vijay; Tessner, Kevin; Trotman, Hanan. Schizophrenia and the psychotic spectrum. Craighead, W. Edward (Ed); Miklowitz, David J (Ed); Craighead, Linda W (Ed). (2008). Psychopathology: History, diagnosis, and empirical foundations. (pp. 402-434). xiv, 704 pp. Hoboken, NJ, US: John Wiley & Sons Inc.

Walker, Elaine; Bollini, Annie; Hochman, Karen; Kestler, Lisa; Mittal, Vijay A. Schizophrenia. Maddux, James E (Ed); Winstead, Barbara A (Ed). (2008). Psychopathology: Foundations for a contemporary understanding (2nd ed.). (pp. 199-222). New York, NY, US: Routledge/Taylor & Francis Group.           

Walder, D. Mittal , V., Trotman, H .McMillan, A. Walker, E. (2008) Neurocognition and conversion to psychosis in adolescents at high-risk. Schizophrenia Research,  101,Issue 1-3, 161-168.

Ostiguy, C.S., Ellenbogen, M.A., Linnen, A., Walker, E.F., Hammen, C., & Hodgins, S. (2009). Chronic stress and stressful life events in the offspring of parents with bipolar disorder. Journal of Affective Disorders, 114, 74-84.

Mittal V. A. and Walker, E.F. (2009) Movement Abnormalities: A Putative Biomarker of Risk for Psychosis.  In Michael  S. Ritsner (Ed.) The Handbook of Neuropsychiatric,Biomarkers, Endophenotypes and Genes. 239-258.

Compton M. T. & Walker, E.F. (2009) Physical Manifestations of Neurodevelopmental Disruption: Are Minor Physical Anomalies Part of the Syndrome of Schizophrenia? Schizophrenia Bulletin vol. 35 no. 2 pp. 425–436.

Compton M.T., Goulding S. M., Ramsay C.E., Addington J., Corcoran C.,Walker E. F. (2008) Early detection and intervention for psychosis: perspectives from North America. Clinical Neuropsychiatry, Vol. 5 (6), 263-272.

King, S., Mancini-Marïe, A., Brunet, A., Walker, E. F., Meaney, M.J., Laplante, D.P. (2009)  Prenatal maternal  stress from a natural disaster predicts dermatoglyphic asymmetry in humans.  Development & Psychopathology, 21: 343-353.

Esterberg ML, Trotman, H, Tessner, K, Mittal, V, Larson, M, Walker, EF (2008). Childhood and current autistic features in individuals with schizotypal personality disorder.  Schizophrenia Research. 104(1-3), 265-273.

Compton, M., Goulding, S & Walker, E (In press) Characteristics of the Retrospectively Assessed Prodromal Period in Hospitalized Patients with First-Episode Nonaffective Psychosis: Findings from a Socially Disadvantaged, Low-Income, Predominantly African American Population. Journal of Clinical Psychiatry.

Brennan, P, Walker, E.F. et al., (2008) Maternal Depression and Infant Cortisol: Influence of timing, comorbidity and treatment. Journal of Child Psychology and Psychiatry, 49(10):1099-107.

Woods S.W, Addington J, Cadenhead K.S, Cannon T.D, Cornblatt B.A., Heinssen R., Perkins D.O., Seidman L.J., Tsuang M.T., Walker E.F., McGlashan T.H. (In press) Validity of the prodromal risk syndrome for first psychosis: Findings from North American Prodrome Longitudinal Study. Schizophrenia Bulletin.  

Rocker, K. Ousley, O. Walker, E. Cubells, J. (2009) Performance on the Modified Card Sorting Test and its Relation to Psychopathology in Adolescents and Young Adults with 22q11.2 Deletion Syndrome" Journal of Intellectual Disability Research. 53(7):665-76.

Compton, M., Walker, E. et al., (2009) Relations of Pre-Onset Cannabis, Alcohol, and Tobacco Use with the Age at Onset of Prodrome and Age at Onset of Psychosis in First-Episode Patients. The American Journal of Psychiatry, 166(11):1251-7. 

Walker, E. et al. (2009) The relation of antipsychotic and antidepressant medication with baseline symptoms and symptom progression: A naturalistic study of the North American Prodrome Longitudinal Sample. Schizophrenia Research. 115(1):50-7.

Woods SW. Addington J. Cadenhead KS. Cannon TD. Cornblatt BA. Heinssen R. Perkins DO. Seidman LJ. Tsuang MT. Walker EF. McGlashan TH. (2009) Validity of the prodromal risk syndrome for first psychosis: findings from the North American Prodrome Longitudinal Study. Schizophrenia Bulletin. 35(5):894-908.

Cornblatt, B., Green, M., Walker, E & Mittal, V (2009) Schizophrenia: Etiology and neurocognition. Blaney, Paul H (Ed); Millon, Theodore (Ed). (2009). Oxford textbook of psychopathology (2nd ed.). (pp. 298-332).

Tessner, K., Mittal, V & Walker, E (In press) Longitudinal study of stressful life events and daily stressors among adolescents at high risk for psychotic disorders. Schizophrenia Bulletin.

Walker, E., Brennan, P., Esterberg, M. & Brasfield, J (In press) Longitudinal changes in cortisol secretion and conversion to psychosis in at-risk youth. Journal of Abnormal Psychology.

Seidman, L. Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF, Woods SW, Bearden CE, Christensen BK, Hawkins K, Heaton R, Keefe RS, Heinssen R, Cornblatt BA, (2010) Neuropsychology of the Prodrome to Psychosis in the NAPLS Consortium: Relationship to Family High Risk and Conversion to Psychosis. Archives of General Psychiatry, 67: 578-88.

Mittal, V., Walker, E.F., Beardon, C., Walder, D., Trotman, H., Daley, M., Simone, A., Cannon T. D. (2010) Markers of Basal Ganglia dysfunction and conversion to psychosis: Neurocognitive deficits and dyskineasias in the prodormal period.  Biological Psychiatry, 68: 93-99.

Walder, D. J. Trotman HD, Cubells JF, Brasfield J, Tang YL, Walker, E.F. (2010) Catechol-O-Methyltransferase (COMT) Modulation of Cortisol Secretion in Psychiatrically At-risk and Healthy Adolescents. Psychiatric Genetics, Vol. 20 (4), pp. 166-70. 

Walker, E. Shapiro, D. Esterberg, M & Trotman, H. (2010) Neurodevelopment and Schizophrenia: Broadening the focus. Current Directions in Psychological Science. 19(4) 204-208.  
           
Larson MK, Walker EF, Compton MT, (2010) Early signs, diagnosis and therapeutics of the prodromal phase of schizophrenia and related psychotic disorders. Expert Review of Neurotherapeutics, 10 (8):1347-59.

Walker E. (2010) Introduction to Special issue on Schizophrenia.  Current Directions in Psychological Science. 19(4), 1-2.

Esterberg, Michelle L.; Trotman, Hanan D.; Holtzman, Carrie; Compton, Michael T.; Walker, Elaine F. (2010) The impact of a family history of psychosis on age-at-onset and positive and negative symptoms of schizophrenia: A meta-analysis. Schizophrenia Research, 120:121-130.

Walker, E. (2010) Facing the ethical challenges of neuroscience: An imperative for science and the public welfare. American Journal of Bioethics: Neuroscience, 1.

Compton, M.T., Goulding, S.M. & Walker, E. F. (2010) Characteristics of the Retrospectively Assessed Prodromal Period in Hospitalized Patients with First-Episode Nonaffective Psychosis: Findings from a Socially Disadvantaged, Low-Income, Predominantly African American Population. Journal of Clinical Psychiatry. 71(10):1279-85.

Cadenhead, K. Addington J, Cannon T.D, Cornblatt B.A., Heinssen R., Perkins D.O., Seidman L.J., Tsuang M.T., Walker E.F., Woods S.W, McGlashan T.H. (2010) Treatment History in the Psychosis Prodrome: Characteristics of the North American Prodrome  Longitudinal Study Cohort. Early Intervention in Psychiatry. 4(3):220-6.

Mittal VA.  Walker EF. (2010) Movement abnormalities and schizophrenia in DSM-V. Psychological Medicine. 40(9):1581-1582.

Esterberg, M.L., Goulding, S.M., & Walker, E.F. (2010). Cluster A Personality Disorders: Schizotypal, schizoid and paranoid personality disorder in youth. Journal of Psychopathology and Behavioral Assessment, 1;32(4):515-528.

Tessner, K., Mittal, V & Walker, E (2011) Longitudinal study of stressful life events and daily stressors among adolescents at high risk for psychotic disorders. Schizophrenia Bulletin. 37: 432-441.

Compton, M.T., Gordon, T.L., Goulding, S.M., Esterberg, M.L., Carter, T., Leiner, A.S., Weiss, P.S., Druss, B., Walker, E.F., & Kaslow, N.J. (2011). Patient-level predictors and clinical correlates of duration of untreated psychosis in an urban, predominantly African American, first-episode sample. Journal of Clinical Psychiatry. 72: 225-232.

Compton, M., Chan, R.C., Walker, E., & Buckley, P. (2011) Minor Physical Anomalies: Potentially Informative Vestiges of Fetal Developmental Disruptions in Schizophrenia. International Journal of Developmental Neuroscience. 29: 245–250.

Walker, E., Trotman, H., Brasfield, J., Esterberg, E. & Larsen, M. (2011) Stress hormones, genes, and neuronal signalling in adolescence: The perfect storm for vulnerability to psychosis. In Kendler, K., Jaffe, s. & Romer, D. The Dynamic Genome and Mental Health. New York, Oxford University Press.

Compton, Michael T., Gordon, Tynessa L. Weiss, Paul S., Walker, E. F. (2011). The “Doses” of Initial, Untreated Hallucinations and Delusions: A Proof-of-Concept Study of Enhanced Predictors of First-Episode Symptomatology and Functioning Relative to Duration of Untreated Psychosis. Journal of Clinical Psychiatry (In Press).

Shapiro, D. Cubells JF, Ousley OY, Rockers K, Walker EF (2011) Prodromal symptoms in adolescents with 22q deletion syndrome.  Schizophrenia Research. (In Press).

Ostiguy, C. S., Ellenbogen, M. A., Walker, C., Walker, E. & Hodgins, S. (2011) Sensitivity to stress among the offspring of parents with bipolar disorder: A study of daytime cortisol levels. Psychological Medicine.28:1-11.

Simeonova DI, Attalla A, Trotman H, Esterberg M, & Walker EF. (2011) Does a parent-report measure of  behavioral problems enhance prediction of psychosis in prodormal youth? (In Press).

Addington, J.  Cadenhead, K. Cannon T.D, Cornblatt B.A., Heinssen R., Perkins D.O., Seidman L.J., Tsuang M.T., Walker E.F., Woods S.W, McGlashan T.H. (2011) At clinical high risk for psychosis: Outcome for nonconverters.  American Journal of Psychiatry.  (In Press).

Mittal, V & Walker, E. (2011) Minor physical anomalies and vulnerability in prodromal
youth. Schizophrenia Research. (In Press).